The 2010–11 Slovak Cup was the forty-second season of Slovakia's annual knock-out football cup competition and the eighteenth since the independence of Slovakia.
As the 22nd ranked league system using the UEFA coefficient, the winners of the competition will earn a place in the third qualifying round of the UEFA Europa League.
ŠK Slovan Bratislava won the cup after beating Žilina 5–4 on penalties.
The eight winners from the third round competed in the two-legged quarterfinals on 2 and 23 November 2010, with the exception of the MŠK Žilina/Tatran Liptovský Mikuláš matches, which took place on 11 November and 1 December 2010.
The four winners from the quarterfinals competed in the two-legged semifinals.