In the middle of the season Windsor & Eton folded due to financial problems, the club was expelled from the league, their record was expunged.
Beaconsfield SYCOB finished bottom of the table were reprieved after Premier Division club Windsor & Eton folded and Atherstone Town resigned from the league.
Totton won the title and were promoted to the Premier Division along with play-off winners Frome Town.
In April 2011 it was announced that Almondsbury Town would resign from the league at the end of the season due to ground problems, and so Andover, the only South & West club that finished in the relegation zone, were reprieved.
1 Hemel Hempsted Town advanced as Windsor & Eton resigned from the Southern League and folded.