The 2010–11 Spartan South Midlands Football League season was the 14th in the history of Spartan South Midlands Football League a football competition in England.
The Premier Division featured 19 clubs which competed in the division last season, along with four new clubs: Also, Kingsbury London Tigers changed name to London Tigers.
Division One featured 17 clubs which competed in the division last season, along with five new clubs:
Division Two featured 14 clubs which competed in the division last season, along with two new clubs: