Al-Jaish are the defending champions, having won their 11th Syrian League title in the previous season for the first time since 2003.

Jableh, and Afrin were relegated to the League 2nd Division after finishing the 2009–10 season in the bottom two places.

Afrin made their immediate return to the second level after just one year in the Syrian top flight, while Jableh ended more than a thirteen-year tenure in Syrian League Where he achieved, including the league title once and runner-up time.

Hutteen and Al-Futowa returned to the highest Syrian football league for the after one year just in the 2nd Division.

[11] Al-Shorta won 1–0 on aggregate and qualified for the 2012 AFC Cup group stage.