Normal season started on 20 August 2010, Friday by Adanaspor-Mersin İdmanyurdu match and ended on 15 May 2011.
Ankaraspor, which was directly relegated from 2009–10 Süper Lig, was dismissed from the federation because the club appealed to a court for that decision.
Ankaraspor was relegated from the Süper Lig by TFF in October 2009 for anti-competitive behaviour.
Güngören Belediyespor returned to First League, were relegated in 2008–2009 season, their first attempt after a 1–0 win against Tokatspor at away match on May 2, 2010.
On 4 August 2010, the TFF dismissed Ankaraspor from the league because the club has gone before the court for the previous year's relegation matters, an out-of-system way that the federation that does not approve against its final decisions.