The 2010–11 Bundesliga season was the 112th in Hoffenheim's history and third consecutive season in the Bundesliga.

They finished in eleventh, accumulating a total of 43 points over 34 games.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

This article about a German association football competition is a stub.