The 2010–11 Toto Cup Al was the twenty-nine season of the third most important football tournament in Israel since its introduction and seventh under the current format.

First, sixteen Premier League teams were divided into four groups.

Quarterfinals, Semifinals and Final were held as one-legged matches, with the Final played at the Ramat Gan Stadium.

The defending champions were Beitar Jerusalem, who made it their second Toto Cup title overall.

[5] The draw for the Semifinals took place on 30 December 2010, with matches played a week later on January 5, 2011.