[1] Brazilian forward Jackson Coelho, nicknamed Jajá, signed for the club on the same day of the Super Cup.

[2] The club started their domestic league season against Ankaragücü on 15 August 2010, winning 2–0, with both goals coming from Gutiérrez.

[3] They also competed in the UEFA Europa League, beginning their campaign against three-time winners Liverpool, and were knocked out after losing 1–3 on aggregate.

[7] Barış Ataş became the club's third signing of the season when he joined on a free transfer from Diyarbakırspor on 22 June 2010.

As a result, Gutiérrez was unable to travel with the team to their pre-season camp in Germany, and was instead left in Istanbul.

[16] Trabzonspor opened up the domestic season by defeating Ankaragücü two to nil, with two second half goals from Teófilo Gutiérrez sealing the match.

[3] Trabzonspor transferred former FC Schalke 04 youth product Volkan Ünlü from feeder club MVV on 17 August.

Trabzonspor signed A2 defender Mert Ege Özeren to a three-year deal on 23 August following Arkadiusz Głowacki's injury.

[20] The win pushed Trabzonspor to the top of the table after two rounds, tied on points with Bursaspor and Kayserispor.

The match finished 2–1 in Trabzonspor's favour, with Engin Baytar and Umut Bulut providing both goals.

Ibrahim Yattara and Teófilo Gutiérrez bagged a brace each, while Selçuk İnan and Burak Yılmaz filled out the scorers' sheet.

Trabzonspor will then travel to face league champions Bursaspor, whom they bested earlier in the season with a three to nil win in the 2010 Turkish Super Cup.

Trabzonspor, along with Bursaspor, Fenerbahçe, and Galatasaray, will be drawn into separate groups and will be joined by sixteen clubs who progress past the play-off round.