The 2010–11 UAE President's Cup is the 35th season of the UAE President's Cup, the premier knockout tournament for association football clubs in the United Arab Emirates.
The format once again changed from the previous season,[citation needed] reverting to a knockout tournament rather than a round-robin groups phase.
The cup winner were guaranteed a place in the 2012 AFC Champions League.
Round 1 consisted of fourteen matches played on 20–21 September 2010.
1 Al Ain were found to have used an ineligible player and were disqualified, Masafi went through.