The season was a disastrous one relative to the success of 2009–10, with the club suffering relegation following the January departures of star players Antonio Cassano and Giampaolo Pazzini.

Source: Competitive matches Based on their finish in the 2009–10 season, Sampdoria began the 2010–11 Coppa Italia in the round of 16.

By finishing in fourth position in Serie A, Sampdoria will play in the play-off round of the Champions League.

The return at Stadio Luigi Ferraris in Genoa saw Sampdoria jump out to an early lead on a pair of Giampaolo Pazzini goals.

In the first half of extra time, Claudio Pizarro scored giving Werder Bremen a 5–4 lead on aggregate.