The 2010–11 USC Trojans men's basketball team represented the University of Southern California during the 2010–11 NCAA Division I men's basketball season.

The Trojans, led by second year head coach Kevin O'Neill, played their home games at the Galen Center and were members of the Pacific-10 Conference.

They finished the season 19–15, 10–8 in Pac-10 play.

They lost in the semifinals of the 2011 Pacific-10 Conference men's basketball tournament to Arizona.

They received an at-large bid to the 2011 NCAA Division I men's basketball tournament where they lost in the new First Four round to VCU.