2010–11 Uruguayan Primera División season

Nacional won their 43rd Primera División title after defeating Defensor Sporting in the season-ending final.

Atenas, Cerrito, and Cerro Largo were relegated after accumulating the fewest points in the season aggregate table.

Defensor Sporting and Nacional qualified to the championship playoffs as the Apertura and Clausura winners, respectively.

Additionally, Nacional re-qualified as the team with the most points in the season aggregate table.

Man of the match: Mauricio Pereyra Assistant referees: William Casavieja Raúl Hartwig Fourth official: Gustavo Siegler