It was reduced to a size of 12 teams from this season following a unanimous decision by the Premier League clubs in June 2009.
Rhyl were denied the domestic licence for competing in this season's Welsh Premier League and were therefore relegated to the second tier.
Teams played each other twice on a home and away basis, before the league split into two groups - the top six and the bottom six.
As Llanelli AFC had already been assured of a Europa League spot by virtue of playing in the 2010–11 Welsh Cup Final against Champions-League qualified Bangor City, third-placed Neath and fifth- through eighth-placed sides Port Talbot Town, Prestatyn Town, Aberystwyth Town and Airbus UK Broughton competed in the inaugural play-offs for the second 2011–12 UEFA Europa League spot available via league placement.
The final was held at Neath's Gnoll, as they had finished higher than Prestatyn in the league and had therefore 'earned' home advantage.