Twenty teams from eleven countries took part in the competition, which ran from 10 December 2010 to 20 April 2011.
ASD Rapallo Nuoto defeated Het Ravijn in the final, overcoming a 7-goals loss in the first leg, to win the competition.
Szentesi VK and SKIF Izmaylovo also reached the semifinals.
[1] It was the seventh time the trophy went to Italy, with Rapallo Nuoto becoming the fourth Italian team to win the competition after Gifa Palermo, CC Ortigia and ASD Roma.
[2] Each national federation can enter up to two teams into the LEN Trophy.