The Musketeers received an at-large bid as a #6 seed to the NCAA tournament where they defeated Minnesota and Pittsburgh before losing to Kansas State in the Sweet Sixteen.

On October 21, 2010, the Musketeers were picked by other Atlantic 10 coaches to finish second in the league standings and received three first place votes.

[1] Jay Bilas of ESPN named Xavier the top team in the Atlantic 10, and praised the coaching job Chris Mack did in his initial season.

[2] Source[3] Tu Holloway had a triple-double as Xavier defeated Wake Forest 83–75 in the Skip Prosser Classic.

David West was the last Xavier player to record a triple-double when he had one against Long Island University on December 8, 2001.