The 2010–11 Primera División season (officially the 2010–11 Copa Movilnet for sponsorship reasons) is the 29th professional season of Venezuela's top-flight football league.
Centro Italo Venezolano and Llaneros were relegated after accumulating the fewest points in the 2009–10 season aggregate table.
They were replaced by Atlético Venezuela and Caroní, the 2009 Segunda División Apertura runner-up and 2010 Segunda División Clausura winner, respectively.
Deportivo Táchira and Zamora qualified to the Serie Final, which was contested on a home and away basis.
Other than the teams which already qualify for the Copa Libertadores (Apertura and Clausura champions and the best-placed team in the aggregate table) and the Copa Sudamericana (Copa Venezuela champion), the eight best-placed teams in the aggregate table will contest in the Serie Sudamericana for the remaining two berths to the Copa Sudamericana, which qualify the two winners to the First Stage.