The regular season (and all games before the final playoffs) started on 29 September 2010, and finished on 30 April 2011.
The three best teams of each group plus a fourth qualified decided with special criteria will play a double leg play-off.
After the regular season of the groups A-A and A-B, the team qualified in the same position play a double game play-off to determine their final position in the table.
[1] 1After the renounce of Turismo de Mérida,[2] Córdoba 2016 accepted the invitation of the Federation to join the playoffs.
[3] Before them, the berth was offered to MyN Puente Genil, but the club denied it.