The 2010 American Express – TED Open was a professional tennis tournament played on outdoor hard courts.

It was the twenty-fourth edition of the tournament which is part of the 2010 ATP Challenger Tour.

It took place in Istanbul, Turkey between 9 and 15 August 2010.

The following players received wildcards into the singles main draw: The following players received a Special Exempt into the singles main draw: The following players received entry from the qualifying draw: Adrian Mannarino def.

Mikhail Kukushkin, 6–4, 3–6, 6–3 Leoš Friedl / Dušan Vemić def.