[19] During the WAC's football preview on July 26 in Salt Lake City, Utah,[20] the Broncos were selected by both the coaches and media as favorites to win the conference.

On August 6 Boise State received 1,215 points to rank 5th in the USA Today preseason poll, one spot ahead their season opening opponent, Virginia Tech.

Boise State started fast, gave up the lead, and scored in the last two minutes of the game to pull off a win over #6 Virginia Tech in one of the premier matchups of college football's opening weekend.

The Broncos recovered a fumble on Tech's second snap of the game which led to a 44-yard Kyle Brotzman FG.

Austin Pettis blocked a punt on Tech's next possession then caught an 8-yard TD pass from Kellen Moore 2 plays later to put the Broncos up 10–0.

The Hokies countered with 2 TD's in the second quarter while Kyle Brotzman added a 47-yard FG to make the score 20–14 at halftime.

However, the Broncos were called for running into the kicker, gave the Hokies a 4th and 5 situation where they went for it and scored on a 28-yard TD pass yet failed on the 2-point conversion.

This game, however, would never be in doubt as the Broncos scored early and often on their way to a 51–6 win over their future Mountain West Conference counterparts.

After an early Kyle Brotzman field goal, Shea McClellin fell on a bad Wyoming snap in the end zone for the Bronco defense's first touchdown of the season and a 10–0 lead.

The Broncos next offensive possession only took 4 plays to go 93 yards and finished with a flea-flicker 58-yard touchdown pass from Kellen Moore to Austin Pettis.

The Broncos went to their bag of tricks for their first score as Austin Pettis took a reverse pitch from QB Kellen Moore and threw a 6-yard touchdown pass to TE Tommy Gallarda.

After a Kyle Brotzman field goal, Kellen Moore found Austin Pettis for a 17-yard touchdown to bring the score to 17–7.

The Broncos turned five Toledo turnovers into 28 points en route to a 57–14 blowout for their 58th straight regular-season home win.

Boise State's defense racked up 4 sacks, 2 by Billy Winn, and gave up less than 100 yards rushing for the third time this season.

With Alabama's loss to South Carolina, Boise State now has the nation's longest winning streak at 19 games.

Boise State only played their starters for the first half, but that was enough to dominate the depleted Spartans 48–0 to extend the nations longest winning streak to 20 games.

Aaron Tevis made a one handed interception in the second quarter and returned it 43 yards for a touchdown, the defenses 3rd TD of the season.

Following a bye week, the Broncos stayed at #2 in the human polls, but got fewer first place votes in all three (11 in the AP, 5 in the Coaches, 14 in the Harris).

With Boise State leaving the WAC, they will not play in 2011 but Hawaii will join the Mountain West as a football only member in 2012 and the series will continue as a conference game.

The Bronco defense held the nations leading passing attack to only 151 yards and recorded 7 sacks, the most in a game this season.

A Kyle Brotzman field goal and Moore's second TD pass (17 yards to Jeremy Avery) brought the score to 38–0 at halftime.

The Bronco offense went away in the second half and Nevada's pistol attack ran all over the Boise State defense scoring 17 straight points to tie the game at 24 with about 5 minutes to play.

On their possession after Nevada tied it up, Boise State answered on their first play with a 79-yard screen pass to Doug Martin to put the Broncos up 31–24.

However, the Broncos scored too fast as Nevada would methodically march the ball down the field eating up 4:40 off the clock and tied the game at 31 with 13 seconds to play.

Kellen Moore went deep and connected on a 53-yard pass to Titus Young to put the Broncos on Nevada's 9 yard line with 2 seconds to play.

Kellen Moore supplied the rest of the first half offense with three touchdown passes (12, 2, 4) with a pair to tight end Kyle Efaw for a halftime score of 29–7.

The ground game took over in the second half with Jeremy Avery, Kellen Moore, and Michael Coughlin all with rushing touchdowns.

The Broncos' next possession also ended with no success when Kellen Moore threw his 6th interception of the season, which led to a Utah field goal, their only score of the game.

They turned the ball over again early in the second quarter when Kyle Efaw fumbled while trying to convert on fourth down.

The Broncos scored again on their next two possessions with a 29-yard Kyle Brotzman field goal and 25 yard touchdown pass from Moore to Tyler Shoemaker to lead 16–3 at halftime.