The 2010 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Great West Conference (GWC) during the 2010 NCAA Division I FCS football season.
Led by second-year head coach Tim Walsh, Cal Poly compiled an overall record of 7–4 with a mark of 2–2 in conference play, placing third in the GWC.
The Mustangs played home games at Alex G. Spanos Stadium in San Luis Obispo, California.
[1][2] Fresno State outscored Cal Poly 17-0 in the second half in the first meeting between the two rivals since 1985.
Bulldogs go to 8-0 vs. FCS/1-AA teams under Pat Hill.