Clemson won its annual series against archrival South Carolina for the first time since 2006 by taking two of three games against the Gamecocks.

On April 21, 3B John Hinson tied a school record by hitting three home runs in a game during the Tigers' 22–4 victory over USC-Upstate.

Both teams finished with an 18–12 conference record, but the Tigers won the tiebreaker due to winning the head-to-head matchup with the Seminoles.

The following night, however, Auburn won 11–10, using a three-run home run by Creede Simpson in the 9th inning to rally past Clemson and force a deciding championship game.

In the 1st game of the super regional, the Crimson Tide used two errors in the 3rd inning to score 4 runs and jump out to a 5–0 lead, then held on to claim a 5–4 victory over the Tigers.

In game three, Clemson erased an early 1–0 deficit to take an 8–1 lead into the ninth inning and held of an Alabama rally to win 8–6 and earn a College World Series bid, the Tigers' eleventh overall and first since 2006.

On June 21, the Tigers defeated #1 national seed Arizona State, 6–3, in a game that was delayed to a 10:00 A.M. (CST) start time due to rain and lightning the previous evening.

The Tigers used strong pitching performances by Casey Harman and Alex Frederick, along with great play on defense, to hold the Sun Devils to only three runs.

Offensively, the Tigers took advantage of a poor outing by ASU starting pitcher Scott Blair and several defensive miscues en route to scoring 6 runs and totaling 14 hits.