The 2010 Copa Libertadores de Fútbol Femenino was the second edition of the Copa Libertadores de Fútbol Femenino, CONMEBOL's premier annual international women's club tournament.

The competition was played in São Paulo state, Brazil, from 2 to 17 October 2010.

[2] Gloria Villamayor and Noelia Cuevas won the top scorer award with 8 goals each.

[3] The draw for the competition took place on 13 September 2010.

[6] The top two teams from each group advanced to the semifinals.