The 2010 Copa Petrobras São Paulo was a professional tennis tournament played on outdoor red clay courts.

It was the seventh edition of the tournament which is part of the 2010 ATP Challenger Tour.

The following players received wildcards into the singles main draw: The following players received a special entry into the singles main draw: The following players received entry from the qualifying draw: The following player received entry as a Lucky loser into the singles main draw: Marcos Daniel def.

Thomaz Bellucci, 6–1, 3–6, 6–3 Franco Ferreiro / André Sá def.

Rui Machado / Daniel Muñoz de la Nava, 3–6, 7–6(2), [10–8]