The 2010 AT&T Cotton Bowl Classic game was a post-season college football bowl game between the Oklahoma State Cowboys, representing Oklahoma State University, from the Big 12 Conference and the Ole Miss Rebels, representing the University of Mississippi, from the Southeastern Conference that took place on Saturday, January 2, 2010, at Cowboys Stadium in Arlington, Texas.
This was also the second meeting between Ole Miss and Oklahoma State in a Cotton Bowl Classic game.
The two teams met in the 2004 Cotton Bowl Classic, which Ole Miss won 31-28 on the arm of quarterback Eli Manning.
Aside from the 2004 and 2009 games, Ole Miss defeated TCU 14–13 in 1956 and lost to Texas 7–12 in 1962.
In this 2010 edition of the Cotton Bowl Classic, Ole Miss defeated Oklahoma State by a score of 21–7.