The 2010 Absa Currie Cup Premier Division was the 72nd season in the competition since it started in 1889.
The competition was contested from 9 July through to 30 October.
It was won by the Sharks, who defeated Western Province 30–10 in the final at Absa Stadium, Durban.
Patrick Lambie was named man-of-the-match for his tally of 25 points, the second highest total scored by an individual in a Currie Cup Final.