Led by ninth-year head coach K. C. Keeler, the Fightin' Blue Hens compiled an overall record of 12–3 with a mark of 6–2 in conference play, sharing the CAA title with William & Mary.
Delaware advanced to the NCAA Division I Football Championship playoffs, where the Fightin' Blue Hens received a first round bye.
They beat Lehigh in the second round, New Hampshire in the quarterfinals, and Georgia Southern in the semifinals before losing to Eastern Washington in the NCAA Division I Championship Game, after leading by 19 points late in the third quarter.
Delaware received one vote in the AP Poll following their wins against Towson and UMass.
[5][6][7] Delaware was forced to revise their 2010 schedule when two Colonial Athletic Association opponents, the Northeastern Huskies and the Hofstra Pride, discontinued their football programs after the 2009 season.