The 2010 Donegal Senior Football Championship was the 88th official edition of the Donegal GAA's premier club Gaelic football tournament for senior graded teams in County Donegal.
Naomh Conaill won the final, for the club's second title.
The quarter-finals were played on Saturday 17 July, Saturday 24 July and Sunday 25 July.
[1] Naomh Conaill won the final at MacCumhaill Park in Ballybofey.
[2] The Donegal Champions went on to reach the final of the 2010 Ulster Senior Club Football Championship, knocking out Cavan champions Kingscourt, Monaghan champions Clontibret O'Neills and Tyrone champions Coalisland along the way.