The second round of qualifying matches for the 2010 FIFA World Cup from the CONCACAF section featured the 13 top-ranked CONCACAF teams in the FIFA World Rankings as of May 2007, along with the 11 winning teams from the first round.
The draw took place on 25 November 2007 in Durban, South Africa.
[2] United States won 9–0 on aggregate and advanced to the third round.
Trinidad and Tobago won 3–2 on aggregate and advanced to the third round.
El Salvador won 3–2 on aggregate and advanced to the third round.