The Men's 50 Freestyle at the 10th FINA World Swimming Championships (25m) was swum 16–17 December 2010 in Dubai, United Arab Emirates.

Preliminary heats and semifinals of the event were on 16 December;[1][2][3] the final on 17 December.

[4] At the start of the event, the existing World (WR) and Championship records (CR) were as follows.

The following records were established during the competition: * Kishida scratched the semifinals, so Dotto (17th) advanced to the semifinals in his place.