The Women's 100 Butterfly at the 10th FINA World Swimming Championships (25m) took place 18–19 December 2010 in Dubai, United Arab Emirates.

The heats and semifinals were swum 18 December;[1][2] the final on 19 December.

[3] 61 individuals swam the event.

[1] Prior to the competition, the existing world and championship records were as follows.

The following records were established during the competition: Semifinal 1 Semifinal 2