Plaisir d'Estruval and Prudent Honour both died instantly after jumping Valentine's, the 13th fence in the Topham Chase on 9 April, a handicap over two miles and 5+1⁄2 furlongs.

[7] Coral bookmakers decided to refund bets placed on race-day for King John's Castle.

[9] Selected quotes from the jockeys including winner at the fifteenth attempt, Tony McCoy, 17-year-old Sam Twiston-Davies who was aiming to become the second-youngest winning jockey ever, and Nina Carberry attempting to be first female rider to win the race:[10] Tony McCoy lined up as the most experienced rider in the race for the fourth consecutive year, having taken over as senior rider from Carl Llewellyn after the 2006 National.

At the opposite extreme, nine riders made their Grand National debut, though only one, Sam Twiston-Davies managed to complete the course, finishing fifth.

Clare Balding served as anchor presenter for the fifth consecutive year with Rishi Persad providing interviews from the jockey's room as well as taking a closer look at the horses in the paddock with Richard Dunwoody.

[13] The commentary team for the 2010 Grand National consisted of Ian Bartlett, Darren Owen and Jim McGrath, who called the winner home for the thirteenth consecutive year.

[14] This was the first time for six years that the team had been reduced from four to three with Tony O'Hehir being dropped in what the BBC called a cost-cutting exercise.

[15] As is tradition, anchor presenter Balding conducted the interviews with the winning connections while Bartlett, Dunwoody and Fitzgerald then took the viewers through a detailed rerun of the race.

Mark Pougatch presented the programme live from Aintree with race commentary called by Cornelius Lysaght and John Hunt.