The 2010 Grand Prix Cycliste de Québec was the first edition of the Grand Prix Cycliste de Québec, one-day professional bicycle road race held in Québec City, Quebec, Canada.

It was held on September 10 as the penultimate event in the 2010 UCI ProTour.

With the 2010 Grand Prix Cycliste de Montréal held two days later on September 12, 2010, the 2010 edition was one of only two stops in North America for the 2010 UCI ProTour.

During the International Cycling Union's visit in 2009, they ranked the course as "demanding" from a technical point of view as Québec City is very hilly, and "exceptional" for the beauty of its setting.

This circuit was well-suited for climbers and those who are used to steep descents.