The 2010 IRB Nations Cup was the fifth edition of the international rugby union tournament, a competition created by the International Rugby Board.

It pits the "A" Teams of the stronger (Tier 1) rugby nations (Argentina Jaguars, Italy A and Scotland A) against some of the Tier 2 and 3 nations (Romania, Namibia and Georgia).

[1] For the fourth consecutive year the event was held in Bucharest, Romania.

Scotland A returned to defend their title, but Namibia were the overall winners of the tournament.

The competition was played over three match days, with three matches played consecutively on each day.