The 2010 JSM Challenger of Champaign–Urbana was a professional tennis tournament played on hard courts.

It was the ninth edition of the tournament which was part of the 2010 ATP Challenger Tour.

It took place in Champaign, United States between 15 and 21 November 2010.

The following players received wildcards into the singles main draw: The following players received a Special Exempt into the singles main draw: The following players received entry from the qualifying draw: Alex Bogomolov Jr. def.

Amer Delić, 5–7, 7–6(7), 6–3 Raven Klaasen / Izak van der Merwe def.