Reserve quarterback Tate Forcier also set a school single-game completion percentage record with a 12-for-12 performance against Bowling Green.

[16] *Source: ESPN.com: 2010 NCAA Football Rankings[17] Michigan opened the 2010 season at home against the Connecticut Huskies, the first ever meeting between the two schools.

[32] Brock Mealer—the brother of Michigan guard Elliot Mealer—led the team onto the field by walking to the banner and touching it, which sparked a standing ovation from the crowd.

[31] Following their win against Connecticut, the Wolverines traveled to South Bend, Indiana to take on their long-time rivals, the Notre Dame Fighting Irish, in their first road game of the season.

Michigan won the previous year's contest on a Tate Forcier to Greg Mathews touchdown pass with 11 seconds remaining in the fourth quarter.

[39] After its dramatic win in South Bend against Notre Dame, Michigan played the Division I FCS Massachusetts Minutemen (UMass) in Ann Arbor, the first ever meeting between the two teams.

On the second play from scrimmage after the kickoff, Jordan Kovacs forced a fumble by Hernandez, and Michigan recovered the ball at their own 45-yard line.

UMass responded with its second touchdown of the quarter on a five-yard pass from Havens to Julian Talley, but missed on the two-point conversion attempt.

[45] On the opening drive of the third quarter, Bowling Green's punter fumbled the ball and it flew into the end zone for a safety, giving Michigan a 30–14 lead.

[46] Michigan's 721 yards of total offense rank as the second most in program history, trailing only the Wolverines' 727-yard effort against Delaware State on October 17, 2009.

During the previous meeting between the two schools, Iowa prevailed 30–28 after Denard Robinson threw an interception with less than one minute remaining in the game.

Michigan responded with a 60-yard touchdown pass to Kevin Koger, but Penn State answered with a 5-yard run by Mike Zordich.

In the second quarter, Illinois took the lead with a touchdown yard run by Nathan Scheelhaase, and completed a 2-point conversion to Ryan Lankford.

[73] Michigan scored first when Cameron Gordon picked up a Purdue fumble and ran it back 58 yards for a touchdown, their first defensive points of the season.

Michigan looked to extend its two-game win streak, but faced a tough challenge, as Wisconsin was ranked 6th in the AP Poll and was fresh off of an 83–20 pounding of Indiana.

During the previous meeting between the two schools, Wisconsin won by a score of 45–24, with Scott Tolzien throwing 5 touchdown passes during the game.

Michigan started the second half by finally getting on the board with 2 touchdowns: a 24-yard reception by Darryl Stonum, and then a 4-yard run by Denard Robinson.

Ohio State won the previous meeting, its sixth straight against Michigan, capitalizing on five Tate Forcier turnovers en route to a 21–10 victory.

Michigan had the best scoring opportunity, as they drove down into the Ohio State red zone before Denard Robinson fumbled the ball during a run.

Ohio State opened the scoring early in the second quarter with a 33-yard field goal by Devin Barclay, and then added to their lead with a 7-yard touchdown reception by Dane Sanzenbacher.

The Buckeyes had a chance to extend their lead at the end of the first half, but a Terrelle Pryor pass was intercepted by Jordan Kovacs in the Michigan endzone.

[81] It was Michigan's seventh straight loss to Ohio State, its longest losing streak to the Buckeyes in school history.

[84][85] For this reason, the Columbus Dispatch reported in May 2011 that Ohio State had delayed the award of its traditional "gold pants" charms for the 2010 victory over Michigan.

[87] Michigan entered the game in search of its 20th total bowl victory, and played an SEC opponent for the 30th time in school history.

[88] Two days before the game, Michigan learned that backup QB Tate Forcier was declared academically ineligible and would not participate in the Gator Bowl.

He also went on to set the Big Ten Conference single-season rushing yards by a quarterback record and was named a Davey O'Brien Award semifinalist.

[122] Following their postseason recognition, Jonas Mouton and Stephen Schilling were invited to participate in the NFL Combine, which was held from February 23 – March 1.

Following the 2011 NFL lockout, the following Wolverines signed: tight end Martell Webb with the Philadelphia Eagles, cornerback James Rogers with the Denver Broncos and offensive lineman Perry Dorrestein with the New York Jets.

[124] Former Wolverine transfers also signed: linebacker Cobrani Mixon from Kent State University with the Detroit Lions and offensive guard Justin Boren ended up in Baltimore Ravens.

The following seniors were initially unsigned: linebacker Obi Ezeh and defensive linemen Greg Banks and Adam Patterson.