The 2010 Millsaps Majors football team represented Millsaps College as a member of the Southern Collegiate Athletic Conference (SCAC) during the 2010 NCAA Division III football season.
On March 1, 2010, Aaron Pelch was named head coach to succeed Mike DuBose.
Pelch, a former Weber State University player and 2001 graduate, was a defensive assistant for DuBose's Majors from 2006 to 2008, before joining Tom Cable's Oakland Raiders staff as a special teams coach in 2009.
Pelch guided the Majors to a 7–3 overall record in his first season, but the team saw its streak of four consecutive SCAC championships snapped by virtue of a 35–21 home loss to DePauw, who finished the year 6–0 in conference play.
For the fifth year in a row, the Majors' offense was the SCAC's highest scoring unit.