The team was coached by Bo Pelini and played their home games at Memorial Stadium in Lincoln, Nebraska.

Due to their victory over Missouri, Nebraska represented the North Division in the 2010 Big 12 Championship Game where they were defeated by Oklahoma 20–23.

The Cornhuskers carried on despite losing a handful of key personnel losses to graduation after 2009, especially Heisman-candidate and #2 overall NFL draft pick DT Ndamukong Suh.

The Nebraska coaching staff remained intact for the third straight year, since the return of Bo Pelini to the program.

On his first carry, Martinez rushed for 46 yards and a touchdown, allowing for Nebraska to extend its ongoing NCAA record of consecutive season-opening victories to 25.

This included three Nebraska players totaling over 100 yards of rushing, an accomplishment not met since 2001 and only the fourth time ever in program history.

The Blackshirts coverage prevented the Huskies from ever getting consistent momentum, and Locker ended the day only 4 of 20 in the air for 70 yards and two interceptions, one of which was returned for a Nebraska TD by junior CB Alfonzo Dennard.

The game was closer than the 17–3 score would indicate, as the Jackrabbits had two touchdowns nullified by penalties, one of them on an interception returned 66 yards to the end zone.

Both teams suffered two interceptions each and Nebraska offered up four fumbles on the day, losing one of them to a fumble-free South Dakota State.

Martinez's efforts helped Nebraska to tally more yards against Kansas State than any other opponent in twenty one years.

The Wildcat offense seemed to have success to start the game, marching down the field on their first possession, until they were stopped on a 4th-and-2 in the Nebraska red zone with no points to show for it.

The Cornhuskers traveled to Stillwater following a disappointing loss to Texas the week prior, hoping to bounce back against their first ranked opponent of the year, the #17 Oklahoma State Cowboys.

With Nebraska's departure from the Big 12 Conference following this season, this was the last league meeting of these teams in a series that dates back to when the Cowboys briefly joined the MVIAA from 1925 to 1928.

Nebraska's withdrawal from Big 12 play after this year ends a historical league affiliation with the Tigers that dates to 1892, when these two programs joined with Kansas and Iowa to form the Western Interstate University Football Association (WIUFA).

The conclusion of the 2010 season will mark the end of a 103-year continuous conference partnership, and leaves the fate of the Victory Bell in question.

Second-year Iowa State Head Coach Paul Rhoads hosted Nebraska in Ames for the first time, as the squads come together for their 105th contest.

Kansas traveled to Lincoln to play the 105th and last game in the NCAA-record longest consecutive season series in all of college football.

[30] Following the Cornhuskers' defeat by the Aggies, Nebraska Defensive Coordinator Carl Pelini was involved in an incident with Brandon Jones, a co-owner of a Texas A&M sports site, TexAgs.

In the second half, Oklahoma held Nebraska scoreless for the first time of the season and managed two field goals in each of the latter periods to win 23–20.

Although there were high hopes for the year, three major goals were not achieved and resulted in a season that ended with a note of disappointment.

Instead, Texas took advantage of Cornhusker mistakes to deny Nebraska a win in the final foreseeable match between the teams.

The Cornhuskers started strong and led 17–0 in the second quarter before the Sooners rallied for 23 points while holding Nebraska to just one more field goal.

Having also lost to Texas A&M in the regular season, the 10–3 Nebraska team was invited to the Holiday Bowl for a rematch with Washington.

Protagonist Saul Goodman discusses the team's fortunes with a mall security guard to distract him while an acquaintance robs a clothing store.