Incumbent Democrat Byron Dorgan was eligible to run for re-election to a fourth term but announced in January 2010 that he would not seek reelection, citing his desire to retire and pursue other interests outside of public life.

[6] Alvin Jaeger Republican Alvin Jaeger Republican Incumbent Republican Alvin Jaeger ran for re-election to a sixth term as North Dakota Secretary of State and defeated a challenge from Democratic nominee Corey Mock, a state representative from Grand Forks.

[12] Wayne Stenehjem Republican Wayne Stenehjem Republican Incumbent Republican Wayne Stenehjem ran for re-election to a fourth term as North Dakota Attorney General and defeated a challenge from Democratic nominee Jeanette Boechler, a personal injury lawyer from Fargo.

[14] Doug Goehring Republican Doug Goehring Republican Incumbent Republican Doug Goehring ran for election to his first full term as North Dakota Agriculture Commissioner and defeated a challenge from Democratic nominee Merle Boucher, the Democratic minority leader of the North Dakota House of Representatives from Rolette.

[16] Cory Fong Republican Cory Fong Republican Incumbent Republican Cory Fong ran for re-election to a second term as North Dakota Tax Commissioner and defeated challenges from Democratic nominee Cynthia Kaldor, a businesswoman and former member of the North Dakota State Board of Higher Education from Mayville,[18] and Libertarian nominee Richard Flattum-Riemers.