The Athletics, led by a trio of promising young starters (Gio González, Trevor Cahill, and Brett Anderson), ultimately posted the American League's lowest earned run average in 2010.

Cahill, along with closer Andrew Bailey, would be rewarded for their strong performance with All-Star selections.

On Mother's Day, Braden pitches the 19th perfect game in major league history against the MLB best team, the Tampa Bay Rays, who for the second time in less than a year were on the wrong side.

In the top of fifth, Evan Longoria broke an unwritten rule by attempting to break up the perfect game with a bunt, but rolled foul and ended up striking out.

All 12,228 fans weren't too thrilled to see Tampa's best hitter try to lay down a bunt, as Manager Joe Maddon said, "to get things going."

September 6, Pennington steals 23rd base, most for an Athletic infielder since Carney Lansford in 1989 and Crisp hits team's first leadoff home run of the season.

September 13, Cust hits 100th career HR and 30-year-old Bobby Cramer earns first career win throwing 5.1 innings (1 ER, 4 H, 4 K), becoming the oldest starting pitcher in franchise history to earn a win in first major league game.

September 27, Ellis hits career 191st double, tying Miguel Tejada for 10th on Oakland's all-time list.

September 28, Braden records career-high eighth pickoff of the season (previous high seven in 2008, 17th of his career).

August 11, Braden throws fourth complete game of the season, most since Mark Mulder threw five in 2004.

Ending August 27, team set franchise record of 18 consecutive games with 6 IP and 3 of less ER by starting pitchers.

Also, 24 consecutive games allowing 5 runs or fewer, second longest AL streak in DH era since 1974 (1980 Royals with 25).

Finished month as the only AL team to have three pitchers in top 10 ERA: Cahill (3rd), Gonzalez (9th), Braden (10th).

May 21–23, completed second sweep of season against San Francisco, outscoring the cross bay rivals 10–1.

Non-injury report P Cedrick Bowers, P Sam Demel (traded to ARI), P Lenny DiNardo, P Fernando Hernández, P Marcus McBeth, P Tyson Ross, P Matt Wright, C Josh Donaldson, C Joel Galarraga, C Anthony Recker, C Max Stassi, IF Adrian Cardenas, IF Grant Green, IF Dallas McPherson, IF Gregorio Petit (traded to TEX), IF Eric Sogard, IF Jemile Weeks, IF Matthew Whitney, OF Corey Brown, OF Matt Carson, OF Michael Taylor, OF Corey Wimberly Bold made appearance with Oakland.

Kane County, Oakland's Low-A team since 2003, signed on with Kansas City for the next two years.

Pacific Coast League (AAA), July 14, 2010 @ Coca-Cola Park, Allentown, Pennsylvania PCL vs. International League, 1–2 Postseason All-Star Selection – Chris Carter Texas League-South (AA), June 30, 2010 @ Citibank Ballpark, Midland, Texas North vs. South, 4–5 Postseason All-Star Selection – Corey Brown, Josh Horton California League (A), June 22, 2010 @ BB&T Coastal Field, Myrtle Beach, South Carolina CAL vs. Carolina League, 4–3 Postseason All-Star Selection – Grant Green, Shawn Haviland, Stephen Parker Midwest League-West (A), June 22, 2010 @ Parkview Field, Fort Wayne, Indiana West vs. East, 2–6 ALL STAR FUTURES GAME July 11, 2010 @ Angel Stadium, Anaheim, California U.S. vs. World, 9–1

Sacramento River Cats Midland RockHounds Stockton Ports Vancouver Canadians Seven player from the organization were assigned to the Phoenix Desert Dogs managed by Dodger's hitting coach Don Mattingly.