The 2010 Oklahoma State Cowboys football team represented Oklahoma State University in the 2010 NCAA Division I FBS football season.

The team was coached by sixth-year head coach Mike Gundy and played their homes game at Boone Pickens Stadium.

They finished the year with an 11–2 record (6–2 Big 12) and a 36–10 victory over Arizona in the Alamo Bowl.

Along the way, the Cowboys set a new school record for wins in a season, with 11.

It was also the fourth 10-win season in the Cowboys' 110-year football history; the others came in 1984, 1987 and 1988.