The women's 4 × 100 metre freestyle relay competition at the 2010 Pan Pacific Swimming Championships took place on August 20 at the William Woollett Jr. Aquatics Center.

[3][4] This race consisted of eight lengths of the pool.

The first swimmer had to touch the wall before the second could leave the starting block.

[5] Prior to this competition, the existing world and Pan Pacific records were as follows: All times are in minutes and seconds.

Heats weren't performed, as only five teams had entered.