The 2010 Paris–Roubaix was the 108th running of the Paris–Roubaix single-day cycling race, often known as the Hell of the North.

It was held on 11 April 2010 over a distance of 259 kilometres (160.9 miles) and was the ninth event in the inaugural UCI World Ranking series.

The race was won by Swiss rider Fabian Cancellara.

[1] There were 25 teams for the 2010 Paris–Roubaix:[2] Teams for Paris-Roubaix Wild Cards