The 2010 Rice Owls football team represented Rice University in the 2010 college football season.

The Owls, led by fourth-year head coach David Bailiff, are members of Conference USA in the West Division and played their home games at Rice Stadium.

They finished the season 4–8, 3–5 in C-USA play.

Irrelevant) DE Cheta Ozougwu by the Houston Texans.

This college football 2010s season article is a stub.