The 2010 Samford Bulldogs team represented Samford University in the 2010 NCAA Division I FCS football season.

The Bulldogs were led by fourth-year head coach Pat Sullivan and played their home games at Seibert Stadium.

They are a member of the Southern Conference.

They finished the season 4–7, 2–6 in SoCon play to finish in seventh place.

This college football 2010s season article is a stub.