The Gamecocks played their home games at Williams–Brice Stadium in Columbia, South Carolina and were members of the East Division of the Southeastern Conference.

The Gamecocks finished the season 9–5, 5–3 in SEC play to win the East Division for the first and only time in program history.

[6][7] Running back Marcus Lattimore, in the only healthy season of his career, was named the National Freshman of the Year.

[20] [21] Quarterback Stephen Garcia and freshman running back Marcus Lattimore each rushed for two touchdowns and USC head coach Steve Spurrier won his 18th straight season opener, 41-13 over Southern Miss.

Freshman backup quarterback Connor Shaw also had a highlight, throwing his first touchdown pass as a Gamecock to wide receiver D.L.

Freshman running back Marcus Lattimore carried for 182 yards and two touchdowns, as #24 South Carolina outmatched #22 Georgia, 17-6, in the SEC opener for both teams.

at Memorial Stadium • Clemson, South Carolina Projected starters and primary backups for SEC Championship Game versus Auburn on December 4, 2010.