The 2010 Tennessee Volunteers football team represented the University of Tennessee in the 2010 NCAA Division I FBS football season.

[2] The Vols played their home games at Neyland Stadium and competed in the Eastern Division of the Southeastern Conference.

Derek Dooley won his coaching debut with the Vols 50–0 versus Tennessee-Martin on September 4, 2010, in front of 99,123 at Neyland Stadium.

They finished the regular season 6–6, 3–5 in SEC play and were invited to the Music City Bowl where they were defeated by North Carolina 30–27.

Oregon would go on to score 45 unanswered points to cruise to an easy 35 point win despite the weather, which appeared to hinder Oregon's fast-paced offense.