The 2010 Brier was without its two-time defending champions, the Kevin Martin Alberta rink, which did not participate in playdowns, instead focusing on the 2010 Winter Olympics.

The 1996 and 1999 Brier champion Jeff Stoughton skipped for Manitoba for the eighth time, a record for that province.

[3] Former Olympic gold medalist Brad Gushue skipped for Newfoundland and Labrador for the seventh time in eight years.

Kevin Koe's Alberta rink defeated Glenn Howard of Ontario in the final with a score of 6–5 to win the 2010 Tim Hortons Brier.

Skip: Kevin Koe Third: Blake MacDonald Second: Carter Rycroft Lead: Nolan Thiessen Alternate: Jamie King Skip: Jeff Richard Third: Tom Shypitka Second: Tyler Orme Lead: Chris Anderson Alternate: Kyle Anderson Skip: Jeff Stoughton Third: Kevin Park Second: Rob Fowler Lead: Steve Gould Alternate: Randy Dutiaume Skip: James Grattan Third: Steve Howard Second: Jason Vaughan Lead: Peter Case Alternate: Bobby Vaughan Skip: Brad Gushue Third: Mark Nichols Second: Ryan Fry Lead: Jamie Korab Alternate: Glenn Goss Skip: Brad Jacobs Third: E. J. Harnden Second: Ryan Harnden Lead: Caleb Flaxey Alternate: Rob Thomas Skip: Ian Fitzner-LeBlanc Third: Stuart MacLean Second: Kent Smith Lead: Phil Crowell Alternate: Mark Robar Skip: Glenn Howard Third: Richard Hart Second: Brent Laing Lead: Craig Savill Alternate: Steve Bice Skip: Rod MacDonald Third: Kevin Champion Second: Mark O'Rourke Lead: Andrew Robinson Alternate: Peter MacDonald Skip: Serge Reid Third: François Gionest Second: Simon Collin Lead: Steeve Villeneuve Alternate: Pierre Charette Skip: Darrell McKee Third: Bruce Korte Second: Roger Korte Lead: Rob Markowsky Alternate: Jason Jacobson Skip: Jamie Koe Third: Kevin Whitehead Second: Brad Chorostkowski Lead: Martin Gavin Alternate: Jon Solberg Final round-robin standings All draw times are listed in Atlantic Standard Time (UTC−4).