The regular season began on 22 March 2010 and ended on 30 September 2010.
Six clubs competed as a quadruple round-robin, for a total of 20 matches.
Daekyo Kangaroos were the defending champions.
Incheon Hyundai Steel Red Angels, Seoul City Amazones and Suwon Facilities Management Corporation players played for the Central team, while Busan Sangmu, Chungnam Ilhwa Chunma and Daekyo Kangaroos players played for the South team.
Suwon FMC won 2–1 on aggregate.