FSV Mainz 05 season is the club's 106th year of existence.

They participated in the Bundesliga, DFB-Pokal and the UEFA Europa League.

On 19 November, the match against Mainz 05 was cancelled after the referee for the match, Babak Rafati, attempted suicide.

[1] The match was eventually rescheduled for 13 December.

[2] Mainz 05 were eliminated from the DFB-Pokal by Holstein Kiel.