AEL Limassol won the championship one matchweek before the end of the season.
Doxa Katokopias and APOP Kinyras were relegated at the end of the first stage of the 2010–11 season after finishing in the bottom two places of the table.
They were joined by AEP Paphos, who finished at the bottom of the second-phase Group C. The relegated teams were replaced by 2010–11 Second Division champions Aris Limassol, runners-up Nea Salamis Famagusta and third-placed team Anagennisi Dherynia.
Note: Flags indicate national team as defined under FIFA eligibility rules.
Players and Managers may hold more than one non-FIFA nationality.